https://orcid.org/0000-0003-2530-6308
Abstract
Purpose
The purpose of this study was to evaluate health-related quality of life (QoL) and explore its predictors in patients with ankylosing spondylitis (AS) in Southwest China.
Patients and Methods
We recruited AS patients from a tertiary hospital in Chengdu, China. Data were collected by self-reported questionnaires, including sociodemographic and disease-related variables, the Medical Outcomes Study 36-Item Short Form (SF-36), Beck Depression Inventory-Second Edition (BDI-II), Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), Bath Ankylosing Spondylitis Functional Index (BASFI), and Bath Ankylosing Spondylitis Global score (BAS-G). Stepwise multiple linear regression analysis was used to determine the factors affecting physical component summary (PCS) and mental component summary (MCS) of SF-36.
Results
A total of 125 patients with AS were included in the current study. The PCS, MCS scores of SF-36 were 41.06±9.12, 47.82±9.84, respectively. Stepwise multiple linear regression analysis showed that higher educational level (β=0.237, P<0.001) and income (β=0.141, P=0.017), lower BASDAI (β=−0.195, P=0.006), BASFI (β=−0.317, P<0.001) and BAS-G (β=−0.288, P<0.001) scores were associated with higher PCS scores of SF-36. Higher BDI-II (β=−0.444, P<0.001) and fatigue (β=−0.293, P<0.001) scores were associated with worse MCS scores of SF-36.
Conclusion
AS patients in Southwest China had impaired health-related QoL. Healthcare providers should take effective strategies to modify the factors affecting health-related QoL, which may prompt disease management and increase QoL.
Data Sharing Statement
The data used in the current study are available from the corresponding author upon reasonable request.
Acknowledgments
The authors appreciate all researchers who contribute to this research work and thank all the patients who participated in this study. A part of this study has been published in Arthritis Research & Therapy, 2021, 23(1):72. https://doi.org/10.1186/s13075-021-02453-7.
Disclosure
The authors declare no conflicts of interest in this work.