https://orcid.org/0000-0002-9978-4276
Abstract
Purpose
We assess whether the sequential mediating effects of self-efficacy and depressive symptoms on the relationship between community efficacy for non-communicable disease management (COEN) and medication adherence and whether these relationships differed by sex and age.
Patients and Methods
Overall, 662 individuals from 12 communities in China were interviewed twice 1 year apart. Serial mediation analysis examined whether the relationship between COEN and medication adherence was mediated by self-efficacy and depressive symptoms. Model invariance across sex and age groups was assessed using multi-group analysis.
Results
Serial mediation analysis indicated that self-efficacy and depressive symptoms sequentially mediated relationship between COEN and medication adherence. Multi-group analysis by sex showed that the path from self-efficacy to medication adherence was significant only for females and from depressive symptoms to medication adherence was significant only for males.
Conclusion
Interventions that enhance individual self-efficacy may be beneficial in decreasing depressive symptoms and improving medication adherence.
Data Sharing Statement
The deidentified data underlying this article will be shared upon written request to and approval by the corresponding author.
Ethics Approval and Informed Consent
All methods were carried out in accordance with relevant guidelines and regulations. This project was approved by the Ethics Committee of Duke Kunshan University (2019YANL013), and Fudan University approved the study. Patients were informed that they could refuse to participate, discontinue their participation at any point, and refuse to answer any questions. Each patient signed a consent form before enrolling in the study. The study complies with the Declaration of Helsinki.
Acknowledgment
We are indebted to Amanda Li for assistance with methodology.
Disclosure
The authors report no conflicts of interest in this work.