Abstract
Delayed hematopoietic recovery and increased rate of engraftment failure limit the use of umbilical cord blood transplantation (UCBT). We describe a case of severe aplastic anemia treated by UCBT combined with mesenchymal stem cells. Our case reveals that infusing mesenchymal stem cells early (about 40 days) after UCBT may promote hematopoietic recovery. This experience will guide clinical scientists, especially hematologists, to deal with similar situations and encourage them to widen this strategy.
Acknowledgments
This work was supported by the National Natural Science Foundation of People’s Republic of China (Grant no 81170492, 81370673), the National High Technology Research and Development Program 863 of People’s Republic of China (Grant no 2012AA022703), the National Key Basic Research Program 973 of People’s Republic of China (Grant no 2010CB732404), the Key Medical Projects of Jiangsu Province (Grant no BL2014078), and the Key Discipline of Jiangsu Province (2011–2015).
Disclosure
The authors declare no conflicts of interest in this work.