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Original Research

Reasons for not initiating osteoporosis therapy among a managed care population

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Pages 821-830 | Published online: 19 Jun 2015
 

Abstract

Background

Many women with osteoporosis do not initiate osteoporosis treatment.

Objective

To examine patients’ reasons for not initiating osteoporosis treatment among women with osteoporosis.

Methods

Survey recipients were identified from a national US claims database and included women ≥55 years with an osteoporosis diagnosis from January 1, 2010 to March 31, 2012 as defined by: 1) osteoporosis diagnosis coupled with bone mineral density test within 183 days of diagnosis and/or 2) osteoporosis-related fracture. Eligibility required no claims for osteoporosis medication 1) at least 12 months and up to 5 years prior to osteoporosis diagnosis and 2) at least 6 months after osteoporosis diagnosis. Continuous enrollment for 18 months (6 months pre-osteoporosis and 12 months post-osteoporosis diagnosis) was also required. A total of 2,000 patients with the most recent osteoporosis diagnosis were mailed a survey. Respondents reporting that they did not initiate physician-recommended osteoporosis medication, after either their physician told them they had osteoporosis or they experienced a fracture since age 45 years, were asked for reasons why they did not initiate treatment.

Results

There were 430 patients who returned a complete survey; mean age was 61% and 21.6% had a fracture. A total of 197 (45.8%) patients reported their physician diagnosed osteoporosis and 117 (59.3%) of those were recommended osteoporosis medication; 44 of the 117 patients (37.6%) did not initiate recommended osteoporosis medication by the time of survey. The primary reasons for not initiating osteoporosis medication were concern over side effects (77.3%), medication costs (34.1%), and pre-existing gastrointestinal concerns (25.0%).

Conclusion

Among respondents, 41% of patients whose physician diagnosed osteoporosis were not recommended osteoporosis treatment and 38% of patients who were recommended osteoporosis treatment did not initiate treatment within approximately 2 years of diagnosis. Concerns with side effects of osteoporosis treatment, medication costs, and pre-existing gastrointestinal concerns were the most common reasons for not initiating recommended treatment.

Acknowledgments

This study was funded by Merck & Co., Inc. Medical writing support was provided by Sarah Peirce-Sandner of Optum, and was funded by Merck & Co., Inc.

Disclosure

Ankita Modi, and Vasilisa Sazonov are employees of Merck & Co., Inc., and Jingbo Yu was an employee at the time of the study and during manuscript development. Susan K Brenneman is an employee of Optum, Eden Prairie, MN, and served as a paid consultant to Merck for the conduct of this study and manuscript development. The authors report no other conflicts of interest in this work.