The use of a single daily dose of tadalafil to treat signs and symptoms of benign prostatic hyperplasia and erectile dysfunction

Abstract

A strong and independent association between lower urinary tract symptoms suggestive of benign prostatic hyperplasia (LUTS/BPH) and erectile dysfunction (ED) has been widely evidenced in several clinical epidemiologic studies. Preclinical animal models have provided a great deal of information on potential common pathogenic mechanisms underlying these two clinical identities. Although the efficacy of the most commonly used treatments for LUTS/BPH is well defined, the negative impact of these treatments on sexual function – in particular, on ED – has triggered the search for new treatment options. In this regard, a new role for phosphodiesterase type 5 inhibitors in the treatment of LUTS/BPH and ED has been claimed. Tadalafil is one of the most extensively investigated phosphodiesterase type 5 inhibitors for this new indication. All evidence reported to date suggests that tadalafil 5 mg once daily is a safe and effective treatment option for both LUTS/BPH and ED.

Keywords:

• phosphodiesterase type 5 inhibitor
• LUTS/BPH
• ED
• sexual function
• Cialis

Disclosure

Matthias Oelke has been advisor, lecturer, or trial investigator for Eli Lilly and Company as well as for Pfizer. Mario Maggi is a scientific consultant for Bayer Pharma AG, Germany and Eli-Lilly Indianapolis, Indiana Other authors declare no conflicts of interest in this work.