Associations Between Kidney Dysfunction and Risk Factors in Patients with Transurethral Resection of the Prostate

Abstract

Purpose

Benign prostate hyperplasia (BPH) with urinary retention can result in kidney dysfunction. Several risk factors might influence deterioration in kidney function. The aims of this study were to assess the association between kidney dysfunction and risk factors in patients with transurethral resection of the prostate (TURP).

Methods

We reviewed medical records of BPH patients managed by TURP and having high levels of blood urea and creatinine. Data collected were age, history of hypertension, diabetes mellitus (DM), urinary tract infection (UTI), urinary retention, and urinary tract stones, duration of obstruction, and blood-urea and -creatinine levels before and after TURP. Chi-suare and paired t- tests were used.

Results

There were 64 patients in the study. More were aged 60–69 years (42.2%) than other age-groups, 53.1% had a history of hypertension, 12.5% DM, 35.9% UTI, all urinary retention, 14.1% urinary tract stones, and 92.2% obstruction duration <14 days. There were significant differences in blood-urea and -creatinine levels between before and after TURP (p<0.001). There were no significant differences between age-group, hypertension, DM, UTI, urinary retention, urinary stones, or duration of obstruction with kidney dysfunction after TURP (p>0.001).

Conclusion

Age, hypertension, DM, UTI, urinary retention, urinary tract stones, and duration of obstruction can be risk factors of kidney dysfunction in TURP patients, and TURP might improve blood-urea and -creatinine levels. There was no significant association between kidney recovery and kidney dysfunction with the number of risk factors in TURP and pre-TURP patients.

Keywords:

• BPH
• TURP
• risk factor
• blood-urea level
• blood-creatinine level
• kidney dysfunction

Ethics Statement

This study was performed in accordance with the Declaration of Helsinki. Data were gathered from the institution database with permission. Patient data were anonymized and confidentiality maintained throughout the study.

Author Contributions

All authors made a significant contribution to the work reported, whether in conception of the study, execution, acquisition of data, analysis, and interpretation, or all these areas, took part in drafting, revising, or critically reviewing the article, gave final approval to the version to be published, have agreed on the journal to which the article has been submitted, and agree to be accountable for all aspects of the work.

Disclosure

The authors certify that there are no conflicts of interest with any financial organization regarding the material discussed in the manuscript.