Sensorimotor polyneuropathy and foot-drop as result of a prostate cancer paraneoplastic syndrome

Abstract

Paraneoplastic syndromes (PNS) vary in incidence and manifestation based on tumor histology. PNS secondary to urologic malignancies have an extremely low incidence. Most reported cases of PNS from urologic malignancies are associated with adenocarcinoma. Peripheral neuropathy-associated PNS from urologic malignancy are exceedingly rare. An 80-year-old male developed a paraneoplastic sensorimotor polyneuropathy and foot-drop after a diagnosis of clinical stage T2cN0M0, Gleason grade 5+4 prostate cancer. A thorough workup is needed in order to adequately assess and treat PNS. Careful analysis must be used to determine the root cause of a patient’s symptoms.

Keywords:

• prostate cancer
• paraneoplastic syndrome
• intensity-modulated radiation therapy
• peripheral neuropathy

Disclosure

This case report was reviewed and written without any funding. The authors have no conflict of interest to disclose in relation to this work.