What is the role of adipokines in myasthenia gravis?

Abstract

Objective

Myasthenia gravis (MG) is a disease with autoimmune etiology. The main pathomechanism is related to the production of antibodies against nicotinic acetylcholine receptor. The present study is aimed to compare the serum level of adipokines in patients with MG with that in controls, as well as to study the relation of these levels with disease severity.

Patients and methods

Fifty patients with MG and 30 healthy individuals were enrolled in our study. Serum concentrations of select adipokines, namely adiponectin, leptin, omentin, visfatin, and resistin were measured.

Results

The results showed a significant increase in serum concentrations of adiponectin and resistin in the patients with MG compared with the controls.

Conclusion

Further studies are warranted to assess changes in adipokine concentration levels in patients with MG.

Keywords:

• adiponectin
• leptin
• resistin
• visfatin
• omentin

Acknowledgments

This study was supported by the Medical University of Silesia.

Disclosure

The authors report no conflicts of interest in this work.