Association between hyperleptinemia and cardiovascular outcomes in patients with coronary artery disease

Abstract

Purpose

Hyperleptinemia has been independently associated with human cardiovascular (CV) diseases. Accordingly, we evaluate the association between serum leptin and future CV events in patients with coronary artery disease (CAD).

Patients and methods

This study enrolled 98 patients with CAD from January to December 2012. The primary endpoint included incidences of major adverse CV events and hospitalization. Patients follow-up had been completed on June 30, 2017.

Results

After a median follow-up of 52 months, 43 CV events had occurred. Patients with CV events had higher systolic blood pressure (P = 0.030), total cholesterol (P = 0.034), C-reactive protein (P = 0.018), and serum leptin levels (P = 0.001) than those without CV events. Kaplan–Meier analysis showed greater cumulative incidences of CV events in the high leptin group (median leptin concentration >6.03 ng/mL) than in the low leptin group (log-rank P = 0.012). Multivariate Cox regression analysis showed that triglyceride (HR: 1.010; 95% CI: 1.001–1.018; P = 0.022) and leptin levels (HR: 1.054; 95% CI: 1.026–1.082; P < 0.001) were independently associated with CV events in patients with CAD.

Conclusion

Serum leptin levels could serve as a biomarker for future CV events in patients with CAD.

Keywords:

• leptin
• coronary artery disease
• cardiovascular events
• triglyceride

Acknowledgments

This study was supported by a grant from the Buddhist Tzu Chi General Hospital, Hualien, Taiwan (TCRD101-03). MC Chen, JH Wang, and BG Hsu conceived and designed the experiments. CJ Lee and JH Wang performed the experiments. CJ Lee and BG Hsu analyzed the data. MC Chen and BG Hsu wrote the manuscript. All authors reviewed and approved the final version of this paper.

Disclosure

The authors report no conflicts of interest in this work.