The impact of intrahepatic cholestasis of pregnancy with hepatitis B virus infection on perinatal outcomes

Abstract

Introduction

To investigate the impact of intrahepatic cholestasis of pregnancy (ICP) with hepatitis B virus (HBV) infection on perinatal outcomes.

Methods

In the study, 200 pregnant women were divided into four groups, including 50 cases with ICP and HBV infection, 50 cases with ICP, 50 cases with HBV infection, and 50 healthy pregnancies. The delivery process and perinatal outcomes were analyzed among different groups.

Results

When compared to the healthy pregnancy group, significantly increased rates of premature rupture of membranes, meconium-stained amniotic fluid, and cesarean section were observed in cases of ICP, HBV infection, or ICP patients with HBV (P<0.05). Specifically, the rates of HBV infection in the newborn, fetal distress, neonatal asphyxia, and birth defects in the newborn, and infant Apgar scores were higher in ICP pregnancies with HBV (56%, 48%, 16%, and 48%, respectively) than in the other groups (P<0.05).

Conclusion

ICP combined with HBV infection has a clear influence on perinatal infant outcomes.

Keywords:

• premature rupture of membranes
• meconium-stained amniotic fluid
• cesarean section
• fetal distress
• neonatal asphyxia
• birth defects
• Apgar scores

Disclosure

The authors report no conflicts of interest in this work.