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Abstract
Asia has a growing diabetic population. Linagliptin, a member of dipeptidyl peptidase-4 inhibitor class, is unique in its nonlinear pharmacokinetics with the characteristics of rapid attainment of steady state, little accumulation, predominantly nonrenal route of elimination, prolonged terminal half-life, and sustained inhibition of dipeptidyl peptidase-4 enzyme. No clinically relevant difference in pharmacokinetics was observed between Asians and non-Asians. The management of type 2 diabetes is increasingly challenging with the progression of disease, especially with the requirements of minimal hypoglycemia, weight gain, fluid retention, and other adverse effects. Linagliptin was efficacious and well-tolerated in Asian type 2 diabetes patients with or without renal or hepatic dysfunctions, comparable to that in Caucasians. This review will focus on the usage of linagliptin in clinical studies in Asians.
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Acknowledgments
Professor Zhi-guang Zhou was supported by the grant of National Clinical Research Center for Metabolic Disease (2013BAI09B12). Dr Yu-fei Xiang was supported by the European Foundation for the Study of Diabetes (EFSD) – China Diabetes Society (CDS)-Lilly Fellowship (2013), the Shenhua Yuying Talent plan of Central South University (2014), and the National Natural Science Foundation of China (Grant no 81400817). Dr Chu-qing Cao was supported by the Fundamental Research Funds for the Central Universities of Central South University (2015zzts306).
Disclosure
The authors report no conflicts of interest in this work.