Ceftaroline fosamil for the treatment of community-acquired bacterial pneumonia in the intensive care unit

Abstract

The Clinical Assessment Program and Teflaro^® Utilization Registry (CAPTURE) is a multicenter study evaluating the clinical use of ceftaroline fosamil in patients with community-acquired bacterial pneumonia (CABP) or acute bacterial skin and skin structure infection. Data were collected between August 2011 and February 2013, from 398 evaluable patients receiving treatment at 33 sites in the USA. This manuscript presents data collected from patients with CABP who received care in an intensive care unit (ICU) or in general medical wards (35% and 64% of evaluable patients, respectively). The majority of ICU and general medical ward patients had underlying comorbidities (78% and 74%, respectively), with structural lung disease being the most common (42% in the ICU and 40% in general medical wards). Patients admitted to the ICU had a longer duration of stay, a longer duration of symptoms before treatment, and a longer duration of ceftaroline fosamil therapy than did general medical ward patients. Most patients treated in the ICU and in general medical wards were given ceftaroline fosamil as second-line therapy (87% and 80%, respectively). The overall rate of clinical success for patients treated with ceftaroline fosamil was 68% in the ICU and 85% in the general medical wards. Clinical success for patients receiving ceftaroline fosamil as a second-line agent was 84% in the ICU and 86% in general medical wards. These findings indicate that ceftaroline fosamil is a viable treatment option for CABP, both in the ICU and in general medical wards.

Keywords:

• CAPTURE
• registry

Acknowledgments

We would like to thank the participating sites, investigators, and staff for their contributions to this study.

CAPTURE is funded by Cerexa, Inc., a wholly owned subsidiary of Forest Laboratories, LLC.

Micron Research Limited assisted in the preparation of this manuscript. This assistance was funded by Forest Laboratories, LLC.

Disclosure

C Maggiore, JA Vazquez, DJ Guervil and A Ramani are study investigators for CAPTURE. JA Vazquez and A Ramani have both received consultancy fees (speaker and advisory board) from Forest Laboratories, LLC. A Jandourek, P Cole and HD Friedland are employees of Cerexa, Inc., a wholly owned subsidiary of Forest Laboratories, LLC.