Clinical Significance of Factor XIII Activity and Monocyte-Derived Microparticles in Cancer Patients

Abstract

Background

The aim was to evaluate factor XIII activity (FXIIIa) and monocyte-derived microparticles (MDMPs) in cancer patients.

Methods

In total, 138 cancer patients (31 malignant lymphomas, 39 multiple myelomas, and 68 lung cancers) were analyzed. We measured various biomarkers including FXIIIa and MDMPs.

Results

The values of endothelial activation markers, monocyte chemoattractant peptide (MCP)-1, soluble (s)CD14, and MDMPs were higher in cancer patients than in non-cancerous controls. MCP-1, sCD14, and MDMPs were significantly correlated with FXIIIa in multivariate analysis in cancer patients. In addition, MCP-1, sCD14, and MDMP levels were significantly increased in the high FXIIIa group of patients. Finally, the survival rate of the high FXIIIa group was significantly poor in the Kaplan–Meier analysis.

Conclusion

These results suggest that abnormal levels of FXIIIa and MDMPs may offer promise as poor prognostic factors in cancer patients.

Keywords:

• factor XIII activity
• cancer
• thrombosis
• endothelial cell
• monocyte-derived microparticle
• MDMP

Abbreviations

RDW-SD, red blood cell distribution width-standard deviation; MPV, mean platelet volume; FXIIIa, factor XIII activity; MCP-1, monocyte chemotactic peptide-1; sCD14, soluble CD14; BMI, body mass index; TF, tissue factor; sE-selectin, soluble E-selectin; sVCAM-1, soluble vascular cell adhison molecule-1; PAI-1, plasminogen activator inhibitor-1; MDMP, monocyte-derived microparticle; LC, lung cancer; ML, malignant lymphoma; MM, multiple myeloma; CAT, cancer-associated thrombosis; VTE, venous thromboembolism.

Acknowledgment

We thank H. Nikki March, PhD, from Edanz Group for editing a draft of this manuscript.

Author Contributions

All authors contributed to data analysis, drafting and revising the article, gave final approval of the version to be published, and agree to be accountable for all aspects of the work.

Disclosure

The authors declare that there are no conflicts of interest.