Effects of astaxanthin supplementation in healthy and obese dogs

Abstract

Background

Since astaxanthin (ASX) has potent anti-oxidative effects with inhibitory action of lipid peroxidation and singlet oxygen quenching activity, it is widely used as a functional food for keeping good health in human. Obesity is a risk factor for various metabolic disorders. It is characterized by low-grade chronic inflammation based on oxidative stress by excessively produced ROS. From the point of preventive medicine, natural compounds have been proposed as potential therapeutic agents in the prevention of metabolic disorder in companion animals. The purpose of this study is to evaluate the effects of ASX supplementation in healthy and obese dogs.

Materials and methods

Ten healthy beagle dogs and 5 clinically obese dogs were used in this study. The healthy beagle dogs were randomly divided into 2 groups as follows: control and test groups. The test group dogs received ASX supplementation mixed with the food for 6 weeks. Five clinically obese dogs received ASX supplementation for 8 weeks. Metabolites, hormones and enzymes were measured before and after ASX supplementation.

Results

In the healthy dog groups, after 6 weeks, plasma triglyceride (TG) and malondialdehyde concentrations and lactate dehydrogenase (LDH) values significantly decreased in the test group. There was no significant difference in the control group. In clinically obese dogs, plasma TG concentration decreased after 8 weeks of ASX supplementation. Plasma alanine aminotransferase and LDH values clearly decreased in all 5 dogs and 4 dogs out of 5 dogs, respectively.

Conclusion

ASX supplementation (0.3 mg/kg body weight/day) for 6 weeks in healthy dogs and 8 weeks in obese dogs induced the elevation of antioxidant function and of liver function by ameliorating lipid metabolism.

Keywords:

• astaxanthin
• obese dogs
• lipid metabolism
• anti-oxidative activity
• liver function

Acknowledgments

The authors thank the staff of the Narita Animal Science Laboratory Co., Ltd for their reliable animal monitoring throughout the study period, and thank the owners of all the dogs for allowing them to participate in this experiment. The authors also thank Dr Atsuhiko Hasegawa and Dr Kohei Suruga for their advice on this manuscript.

Disclosure

Kumi Tominaga is a resercher working in AstaReal Co.Ltd. The authors report no other conflicts of interest in this work.