Emerging insights into the genetic basis of canine hip dysplasia

Abstract

Canine hip dysplasia (CHD) is the most common inherited polygenic orthopedic trait in dogs with the phenotype influenced also by environmental factors. This trait was described in the dog in 1935 and leads to a debilitating secondary hip osteoarthritis. The diagnosis is confirmed radiographically by evaluating signs of degenerative joint disease, incongruence, and/or passive hip joint laxity. There is no ideal medical or surgical treatment so prevention based on controlled breeding is the optimal approach. The definitive CHD diagnosis based on radiographic examination involves the exposure to ionizing radiation under general anesthesia or heavy sedation but the image does not reveal the underlying genetic quality of the dog. Phenotypic expression of CHD is modified by environmental factors and dogs with a normal phenotype can be carriers of some mutations and transmit these genes to their offspring. Programs based on selection of dogs with better individual phenotypes for breeding are effective when strictly applied but remain inferior to the selection of dogs based on estimation of breeding values. Molecular studies for dissecting the genetic basis of CHD are ongoing, but progress has been slow. In the future, the recommended method to improve hip quality in controlled breeding schemes, which will allow higher selection pressure, would be based on the estimation of the genomic breeding value. Since 2012, a commercial DNA test has been available for Labrador Retrievers using a blood sample and provides a probability for development of CHD but we await evidence that this test reduces the incidence or severity of CHD.

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Keywords:

• canine hip dysplasia
• phenotype
• breeding stock
• GWAS
• screening
• diagnosis

Acknowledgments

C Ginja received funding from the European Union Seventh Framework Programme (FP7/2007-2013) under grant agreement number PCOFUND-GA-2009-246542 and from the Fundação para a Ciência e a Tecnologia, Portugal, through a Marie Curie/Welcome II fellowship (Ref DFRH/WIIA/15/2011). The authors are grateful to R Todhunter (College of Veterinary Medicine, Cornell University) for expert critical review of the manuscript and helpful comments.

Disclosure

The authors declare no conflicts of interest regarding this work.