A young man with acute dilated cardiomyopathy associated with methylphenidate

Abstract

An 18-year-old obese man with a body mass index of 40, diagnosed with attention-deficit hyperactivity disorder and treated with methylphenidate (Concerta^®) was acutely admitted to hospital with hypoxia and dyspnoea. On investigation signs of liver-, renal-, and heart-failure were found. Noradrenalin infusion was started. Echocardiography showed dilated left ventricle and an ejection fraction (EF) of 25%. Liver function improved, noradrenalin and dobutamine were tapered, but three days after admission a new echocardiography showed an EF of 10%. The patient was transferred to the National Hospital (Rikshospitalet, Oslo), where intensified treatment including intra aortic balloon pump (IABP) was instituted. Cardiac function improved, and 3 weeks later the IABP was disconnected. EF at this point was 15%. The patient was denied heart transplantation due to various cofactors. The investigation concluded with a probable relationship between his cardiomyopathy and the use of methylphenidate (Concerta).

Keywords:

• cardiomyopathy
• heart failure
• ADHD
• methylphenidate

Heart failure due to idiopathic dilated cardiomyopathy (DCM) is rare in young people. Familial linkage is often found (Seidman and Seidman 2001), and various drugs, especially cytotoxic drugs, may cause cardiomyopathy (Giordano et al 2002). Cocaine and amphetamines are known to have caused DCM (Lange and Hillis 2001). There are very few reports linking methylphenidate therapy to DCM, but recently the Journal of the Norwegian Medical Association described how a young boy treated with methylphenidate died of dilated cardiomyopathy (Tollofsrud and Hoel 2006). We report a similar case but with a different outcome.

Case description

An 18-year-old male was diagnosed with attention-deficit hyperactivity disorder (ADHD) in 2005. He was overweight with a body mass index (BMI) of 40. He was started on quetiapine fumarate (Seroquel^®) 900 mg daily in April 2005 and methylphenidate (Concerta^®) 54 mg daily in September 2005. In the beginning of August 2006 he was admitted to his local hospital with severe dyspnoea, tachypnea, tachycardia, and cyanosis. On admission the blood pressure was 120/80 mmHg, and the arterial blood gas revealed a pH of 7.45, pCO2 of 3.55 kPa, paO2 of 7.76 kPa, and BE of −5.1 mmol/l. C-reactive protein was not elevated. The chest X-ray showed an enlarged heart. He developed hemoptysis and was treated with unfractionated heparin in suspicion of pulmonary embolism. He subsequently developed cardiogenic shock and was treated with vasoactive drugs. In spite of the treatment he became oliguric and his liver enzymes were rising. He was referred to our hospital for further treatment. On admission the blood pressure was 90/60 mmHg, despite infusion with noradrenaline. His heart rate was 130/minute and his temperature was 38.4 °C. A thoracic computed tomography scan did not show pulmonary embolism. Echocardiography revealed biventricular failure and left ventricular end diastolic diameter was 7 cm. The left ventricle was severely hypokinetic with an ejection fraction (EF) of 20%–25%. The left ventricular end diastolic pressure was markedly elevated, and there was a moderate mitral regurgitation. Intermittent hemodialysis was initiated. His liver function improved slightly, but despite dialysis the renal function deteriorated with increasing creatinine values. After three days there was a further worsening of the left ventricular systolic function with an ejection fraction of 10%–12% and marked pulmonary hypertension with systolic pulmonary pressure estimated to 30 mmHg. The clinical picture resembled dilated cardiomyopathy with low output failure causing renal and liver failure. We suspected drug-induced cardiomyopathy and methylphenidate and quetiapine fumarate were discontinued. Screening for infectious pathogens, immunological markers, and iron or amyloid deposition were all negative. After three days he was transferred to the National Hospital (Rikshospitalet, Oslo) with ongoing noradrenaline and dobutamine infusions. Shortly after admission an intraaortic balloon pump (IABP) was inserted and noradrenaline was replaced by nitroprusside. Coronary angiography was normal. Endomyocardial biopsy from the right ventricle did not reveal any distinct myocardial pathology. On treatment with IABP, nitroprusside, and dialysis, the clinical situation gradually improved and the liver function returned to normal. His renal function also improved with increasing diuresis and creatinine fell from 798 to 98 μmol/l. His EF was still markedly reduced (15%). Because of behavioral problems and adipose stature, he was denied a heart transplant. He was treated with IABP for 26 days, and after 28 days he was transferred back to our hospital. At that time his liver and renal functions were normal. He was treated with an angiotensin-converting enzyme (ACE)-inhibitor, a beta-blocker, and diuretics. During the following two weeks his clinical status improved and he was subsequently discharged to his home. The echocardiography still showed markedly dilated left ventricle with EF of 20%.

In March 2007, his clinical status was improved and he was in function class II (New York Heart Association) with an EF estimated by echocardiography to 30%–35%.

Discussion

Our patient presented with progressive cardiac failure leading to liver and renal failure. Previously he was diagnosed with ADHD and was treated with methylphenidate and quetiapine fumarate. The Journal of the Norwegian Medical Association recently presented a case describing a 17-year-old boy who died from dilated cardiomyopathy. Treatment with methylphenidate (Ritalin^®) for 10 years was suspected to be the cause (Tollofsrud and Hoel 2006).

Cardiac adverse effects from methylphenidate have been shown to affect myocardial ultra-structure in rats. This effect was irreversible after 12 weeks (Henderson and Fischer 1995). Methylphenidate is a drug with central nervous stimulating action and with similar effects as amphetamines. Both increase synaptic and intracellular dopamine in rodents and baboons (Schiffer et al 2006). For amphetamine the mechanism has been shown to be both increased release of catecholamines and a blockade of their synaptic reuptake and degradation (Knepper et al 1988). It is the increase in adrenergic action that is believed to be cardiotoxic over time and promote cardiomyopathy (Lange and Hillis 2001). Thus, in transgenic mice, myocardial overexpression of beta-adrenergic receptors was associated with myocyte apoptosis and the development of dilated cardiomyopathy (Singh et al 2001).

With a BMI of 40 our patient had extreme obesity. The hyperdynamic circulation, with increased cardiac output, thought to be a compensatory adaptation to increased adipose tissue may, at the expense of left ventricular hypertrophy and remodeling, lead to nonischemic dilated cardiomyopathy in severe obese subjects (McGavock et al 2006). This is, however, unlikely as the only cause in our young patient. Human obesity is also characterized by sympathetic nervous activation (Eikelis and Esler 2005). A possible obesity-linked susceptibility to the toxic effect of methylphenidate could therefore play a role in the development of DCM in our patient, especially with regards to the short treatment time of one year. In comparison, the previously reported patient had been treated with the same drug for 10 years (Tollofsrud and Hoel 2006).

There is one report of myocarditis associated with quetiapine (Roesch-Ely 2002), and our patient had been treated with quetiapine for 17 months when he was admitted to our hospital. This drug could therefore also play a role in the development of DCM. There was, however, no signs of myocarditis or any other distinct pathology on myocardial biopsy.

In February 2006, an advisory committee to the U.S. Food and Drug Administration (FDA) urged the most serious FDA warning, the “black box”, be placed on all drugs prescribed to treat ADHD (Nissen 2006). The concern, however, was not restricted to cardiomyopathy alone, but to various cardiovascular side effects. After this report, the Norwegian and European Medicines Agency also pay close attention to reports on cardiovascular side effects of these drugs (Madsen 2006).

Conclusion

We report the second case in a short time in Norway of serious cardiomyopathy in young patients treated with methylphenidate. The concern is that methylphenidate is the responsible agent. Although the number treated with this drug is high, and the reported cardiovascular side effects are few, we are concerned about the serious infliction this side effect could have on children and young adults. To our knowledge, there are no guidelines regarding how to identify individuals prone to develop cardiomyopathy due to central stimulating drugs. Further studies addressing this problem need to be done.