Toxicogenomics in Drug Discovery and Development: Mechanistic Analysis of Compound/Class-Dependent Effects Using the Drugmatrix^® Database

Abstract

A range of genomics technologies are increasingly becoming integrated with existing scientific disciplines to broaden and strengthen existing capabilities and open new avenues of research in drug discovery and development. Examples of these new research fields are proteomics, pharmacogenomics, metabolomics and toxicogenomics. Here we review the application of toxicogenomics to improve the evaluation of drug safety, mechanism of action and toxicity in the drug discovery and development process.

Keywords: :

• drug discovery and development
• inducible nitric oxide synthase
• mechanism of action
• mechanism of toxicity
• microarray expression data
• CYP gene expression
• phosphodiesterase inhibitors
• RXR protein function
• toxicogenomics

Acknowledgement

The authors would like to thank Richard Brennan, Gwo-Jen Day and Amy Yang, for critical reading of the manuscript and everyone else at the company for helpful discussions.