Polymorphisms of the ABCB1 Gene are Associated with the Therapeutic Response to Risperidone in Chinese Schizophrenia Patients

Abstract

P-glycoprotein, a product of the ATP-binding cassette B1 (ABCB1) gene, plays an important role in absorption and distribution of drugs. The brain entry of risperidone and 9-OH-risperidone is greatly limited by P-glycoprotein, which implies that the functional polymorphisms of ABCB1 in humans may be a factor contributing to the variability in response to risperidone. The present study was therefore designed to examine whether polymorphisms of the ABCB1 gene are related to therapeutic response. For this purpose, 130 Chinese schizophrenia patients undergoing risperidone treatment were recruited. Plasma drug concentrations were monitored and clinical symptoms were evaluated using the Brief Psychiatric Rating Scale (BPRS) before and 8 weeks after the treatment. Association tests between genotypes and percentage improvement in total BPRS scores were performed using analyses of variance. Our results show that genotyping C1236T may help to predict the efficacy of risperidone treatment on the basis that patients with the TT genotype showed greater improvement than those with other genotypes on the overall BPRS (F = 3.967, p = 0.021), while other polymorphisms, including rs13233308, G2677T/A and C3435T polymorphism, did not show any association with the response to risperidone. These results showed suggestive evidence that genetic variation in the ABCB1 gene may influence the individual response to risperidone.

Keywords: :

• ABCB1
• polymorphism
• response
• risperidone

Acknowledgements

This work was supported by grants from the Shanghai Municipal Commission for Science and Technology, the national 973 and 863 Programs, the Chinese Ministry of Education, and the National Natural Science Foundation of China.

Additional information

Funding

This work was supported by grants from the Shanghai Municipal Commission for Science and Technology, the national 973 and 863 Programs, the Chinese Ministry of Education, and the National Natural Science Foundation of China.