Homocysteine as an Emerging Risk Factor for Cardiovascular Disease in the Elderly

Betti Giusti1 Department of Medical and Surgical Critical Care and Center of Research, Transfer and High Education, “DENOTHE”, University of Florence, viale Morgagni 85, 50134Florence, Italy Tel.: +39 055 794 9420; Fax: +39 055 794 9418;2 E-mail: [email protected]

Anna Maria Gori1 Department of Medical and Surgical Critical Care and Center of Research, Transfer and High Education, “DENOTHE”, University of Florence, viale Morgagni 85, 50134Florence, Italy Tel.: +39 055 794 9420; Fax: +39 055 794 9418;3 E-mail: [email protected]

Rossella Marcucci1 Department of Medical and Surgical Critical Care and Center of Research, Transfer and High Education, “DENOTHE”, University of Florence, viale Morgagni 85, 50134Florence, Italy Tel.: +39 055 794 9420; Fax: +39 055 794 9418;4 E-mail: [email protected]

Claudia Saracini1 Department of Medical and Surgical Critical Care and Center of Research, Transfer and High Education, “DENOTHE”, University of Florence, viale Morgagni 85, 50134Florence, Italy Tel.: +39 055 794 9420; Fax: +39 055 794 9418

Paola Bolli1 Department of Medical and Surgical Critical Care and Center of Research, Transfer and High Education, “DENOTHE”, University of Florence, viale Morgagni 85, 50134Florence, Italy Tel.: +39 055 794 9420; Fax: +39 055 794 9418;5 Centro S Maria agli Ulivi Fondazione Don Carlo Gnocchi Onlus IRCCS, Impruneta, Florence, Italy

Rosanna Abbate1 Department of Medical and Surgical Critical Care and Center of Research, Transfer and High Education, “DENOTHE”, University of Florence, viale Morgagni 85, 50134Florence, Italy Tel.: +39 055 794 9420; Fax: +39 055 794 9418;6 E-mail: [email protected]

Abstract

With longer average life expectancy, the prevalence of cardiovascular disease in later life is rising. A growing body of epidemiological evidence has shown a strong association between elevated homocysteine plasma levels and cardiovascular disease in the general population. This review focuses on the role of homocysteine as an emerging risk factor for cardiovascular disease in the elderly. The possibility of a relatively easy correction of hyperhomocysteinemia by vitamin supplementation represents an important stimulus to reach a definitive conclusion regarding the pathophysiological role of homocysteine as risk factor for cardiovascular disease in the general population and, in particular, elderly subjects.

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Homocysteine as an Emerging Risk Factor for Cardiovascular Disease in the Elderly

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Homocysteine as an Emerging Risk Factor for Cardiovascular Disease in the Elderly

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