Pharmacokinetics of Experimental Antiretroviral Agents

Abstract

Many novel agents are being developed for the management of HIV-1 infection. In currently available classes, there are new protease inhibitors, non-nucleoside and nucleotide reverse transcriptase inhibitors, all in various stages of development. Novel classes include co-receptor entry antagonists (e.g., CCR5 inhibitors) as well as integrase and maturation inhibitors. Data on the pharmacodynamics and the pharmacokinetics of these new agents continue to generate interest. This article will report on the known data of the pharmacokinetics of experimental antiretrovirals, particularly concentrating on recently presented data, and describe the main drug–drug interactions studied to date.

Keywords: :

• antiretroviral therapy
• HIV
• integrase inhibitors
• maturation inhibitors
• pharmacokinetics