Advanced search
Publication Cover
Future Lipidology Volume 2, 2007 - Issue 4
Journal homepage
1,147
Views
170
CrossRef citations to date
0
Altmetric
Reviews

Long-Chain Acyl-Coa Synthetases And Fatty Acid Channeling

Douglas G MashekUniversity of Minnesota, Department of Food Science and Nutrition, St. Paul, Minnesota, 55108, USA Tex.: +1 612 626 2904, Fax.: +1 612 625 5272, E-mail:[email protected]
,
Lei O LiUniversity of North Carolina, Department of Nutrition, Chapel Hill,, North Carolina, 27599, USA Tex.: +1 919 966 1038, Fax.: +1 919 843 8555, E-mail:[email protected]
&
Rosalind A ColemanUniversity of North Carolina, Department of Nutrition, CB# 7461, Chapel Hill, NC 27599–7461, USA Tex.: +1 919 966 7213, Fax.: +1 919 843 8555, E-mail:[email protected]Correspondence[email protected]
Pages 465-476 | Published online: 18 Jan 2017
 
Sample our Food Science & Technology journals, sign in here to start your access, latest two full volumes FREE to you for 14 days

Abstract

Thirteen homologous proteins comprise the long-chain acyl-CoA synthetase (ACSL), fatty acid transport protein (FATP), and bubblegum (ACSBG) subfamilies that activate long-chain and very-long-chain fatty acids to form acyl-CoAs. Gain- and loss-of-function studies show marked differences in the ability of these enzymes to channel fatty acids into different pathways of complex lipid synthesis. Furthermore, the ability of the ACSLs and FATPs to enhance cellular FA uptake does not always require these proteins to be present on the plasma membrane; instead, fatty acid uptake can be increased by enhancing its conversion to acyl-CoA and its metabolism in downstream pathways. Since altered fatty acid metabolism is a hallmark of numerous metabolic diseases and pathological conditions, the ACSL, FATP and ACSBG isoforms are likely to play important roles in disease etiology.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related Research Data

Obesity and Cancer Progression: Is There a Role of Fatty Acid Metabolism?
Source: Hindawi Limited
Proteomic Analysis of Proteins Associated with Lipid Droplets of Basal and Lipolytically Stimulated 3T3-L1 Adipocytes *
Source: American Society for Biochemistry & Molecular Biology (ASBMB)
The genomes of polyextremophilic Cyanidiales contain 1% horizontally transferred genes with diverse adaptive functions
Source: bioRxiv
FACL4, a new gene encoding long-chain acyl-CoA synthetase 4, is deleted in a family with Alport syndrome, elliptocytosis, and mental retardation.
Source: Elsevier BV
The ACSL3-LPIAT1 signaling drives prostaglandin synthesis in non-small cell lung cancer.
Source: Springer Nature
Cellular and Molecular Responses of Dunaliella tertiolecta by Expression of a Plant Medium Chain Length Fatty Acid Specific Acyl-ACP Thioesterase.
Source: Frontiers Media SA
Cloning and functional expression of a novel long-chain acyl-CoA synthetase expressed in brain.
Source: Oxford University Press (OUP)
Impact on fatty acid metabolism and differential localization of FATP1 and FAT/CD36 proteins delivered in cultured human muscle cells
Source: American Physiological Society
Impaired expression of acyl-CoA synthetase 5 in sporadic colorectal adenocarcinomas
Source: Wiley
Cloning of wrinkle-free, a previously uncharacterized mouse mutation, reveals crucial roles for fatty acid transport protein 4 in skin and hair development
Source: Proceedings of the National Academy of Sciences
Saccharomyces cerevisiae contains four fatty acid activation (FAA) genes: an assessment of their role in regulating protein N-myristoylation and cellular lipid metabolism.
Source: Rockefeller University Press
Association of an ACSL1 gene variant with polyunsaturated fatty acids in bovine skeletal muscle
Source: BMC
Fatty acid-induced β cell apoptosis: A link between obesity and diabetes
Source: Proceedings of the National Academy of Sciences
Enzymatic properties of purified murine fatty acid transport protein 4 and analysis of acyl-CoA synthetase activities in tissues from FATP4 null mice.
Source: American Society for Biochemistry & Molecular Biology (ASBMB)
Fusion of TEL/ETV6 to a novel ACS2 in myelodysplastic syndrome and acute myelogenous leukemia with t(5;12)(q31;p13)
Source: Wiley
Phospholipid synthesis fueled by lipid droplets drives the structural development of poliovirus replication organelles.
Source: Public Library of Science (PLoS)
Characterization of long-chain acyl-CoA synthetases which stimulate secretion of fatty acids in green algae Chlamydomonas reinhardtii.
Source: Springer Science and Business Media LLC
Proteomic profiling of lipid droplet proteins in hepatoma cell lines expressing hepatitis C virus core protein
Source: Oxford University Press (OUP)
Chinese hamster ovary K2 cell lipid droplets appear to be metabolic organelles involved in membrane traffic.
Source: American Society for Biochemistry & Molecular Biology (ASBMB)
Post-translational modifications of rat liver mitochondrial outer membrane proteins identified by mass spectrometry.
Source: Elsevier BV
The N-terminal region of acyl-CoA synthetase 3 is essential for both the localization on lipid droplets and the function in fatty acid uptake
Source: American Society for Biochemistry & Molecular Biology (ASBMB)
Regulation of the murine adipocyte fatty acid transporter gene by insulin
Source: The Endocrine Society
Saturated Fatty Acid-induced Apoptosis in MDA-MB-231 Breast Cancer Cells: A ROLE FOR CARDIOLIPIN *
Source: American Society for Biochemistry & Molecular Biology (ASBMB)
PPARγ activation and lipid saturation status
Source: Wiley
Very long-chain acyl-CoA synthetases. Human "bubblegum" represents a new family of proteins capable of activating very long-chain fatty acids.
Source: American Society for Biochemistry & Molecular Biology (ASBMB)
Compositional Changes Among Triglycerides and Phospholipids During FATP4 Sensitization with Palmitate Lead to ER Stress in Cultured Cells
Source: Wiley
Activation of the ATP-sensitive K+ channel by long chain acyl-CoA. A role in modulation of pancreatic beta-cell glucose sensitivity
Source: Elsevier BV
Marked enhancement of acyl-CoA synthetase activity and mRNA, paralleled to lipoprotein lipase mRNA, in adipose tissues of Zucker obese rats (fa/fa).
Source: Elsevier BV
Acyl-CoA synthetase 2 overexpression enhances fatty acid internalization and neurite outgrowth.
Source: American Society for Biochemistry & Molecular Biology (ASBMB)
Physiological Consequences of Compartmentalized Acyl-CoA Metabolism *
Source: The University of North Carolina at Chapel Hill University Libraries
Rat long-chain acyl-CoA synthetase mRNA, protein, and activity vary in tissue distribution and in response to diet.
Source: The University of North Carolina at Chapel Hill University Libraries
Inhibition of acyl-CoA synthetase by triacsins
Source: Elsevier BV
Transmembrane Movement of Exogenous Long-Chain Fatty Acids: Proteins, Enzymes, and Vectorial Esterification
Source: American Society for Microbiology
Long chain fatty acyl-CoA synthetase 5 expression is induced by insulin and glucose: involvement of sterol regulatory element-binding protein-1c.
Source: Elsevier BV
Overexpression of acyl-CoA synthetase-1 increases lipid deposition in hepatic (HepG2) cells and rodent liver in vivo
Source: American Physiological Society
Molecular Characterization and Expression of Rat Acyl-CoA Synthetase 3
Source: Elsevier BV
Revised nomenclature for the mammalian long-chain acyl-CoA synthetase gene family.
Source: The University of North Carolina at Chapel Hill University Libraries
Transcriptome and gene expression analysis of DHA producer Aurantiochytrium under low temperature conditions
Source: Springer Science and Business Media LLC
Lxr-driven enterocyte lipid droplet formation delays transport of ingested lipids
Source: American Society for Biochemistry & Molecular Biology (ASBMB)
Murine bubblegum orthologue is a microsomal very long-chain acyl-CoA synthetase.
Source: Portland Press Ltd.
Hepatic triacylglycerol hydrolysis regulates peroxisome proliferator-activated receptor α activity
Source: Elsevier
Inactivation of fatty acid transport protein 1 prevents fat-induced insulin resistance in skeletal muscle
Source: American Society for Clinical Investigation
Insulin Causes Fatty Acid Transport Protein Translocation and Enhanced Fatty Acid Uptake in Adipocytes
Source: Elsevier BV
Rat long chain acyl-CoA synthetase 5 increases fatty acid uptake and partitioning to cellular triacylglycerol in McArdle-RH7777 cells.
Source: The University of North Carolina at Chapel Hill University Libraries
A novel acyl-CoA synthetase, ACS5, expressed in intestinal epithelial cells and proliferating preadipocytes.
Source: Oxford University Press (OUP)
Solute Carrier Family 27 Member 4 (SLC27A4) Enhances Cell Growth, Migration, and Invasion in Breast Cancer Cells
Source: MDPI AG
miR-34a-5p Increases Hepatic Triglycerides and Total Cholesterol Levels by Regulating ACSL1 Protein Expression in Laying Hens
Source: MDPI AG
Triacsin C blocks de novo synthesis of glycerolipids and cholesterol esters but not recycling of fatty acid into phospholipid: evidence for functionally separate pools of acyl-CoA
Source: Portland Press Ltd.
Association of a long-chain fatty acid-CoA ligase 4 gene polymorphism with depression and with enhanced niacin-induced dermal erythema.
Source: Wiley
Eicosapentaenoic acid-induced apoptosis depends on acyl CoA-synthetase.
Source: Wiley
The Acyl-CoA Synthetase “Bubblegum” (Lipidosin) FURTHER CHARACTERIZATION AND ROLE IN NEURONAL FATTY ACID β-OXIDATION
Source: Elsevier BV
Alterations in intestinal fatty acid metabolism in inflammatory bowel disease.
Source: Elsevier BV
Identification of major proteins in the lipid droplet-enriched fraction isolated from the human hepatocyte cell line HuH7
Source: Elsevier BV
Overexpression of Rat Long Chain Acyl-CoA Synthetase 1 Alters Fatty Acid Metabolism in Rat Primary Hepatocytes
Source: American Society for Biochemistry & Molecular Biology (ASBMB)
Effects of dietary lipids on the hepatopancreas transcriptome of Chinese mitten crab (Eriocheir sinensis).
Source: Public Library of Science (PLoS)
Saturated fatty acids induce endoplasmic reticulum stress and apoptosis independently of ceramide in liver cells
Source: American Physiological Society
Defective fatty acid oxidation in mice with muscle-specific acyl-CoA synthetase 1 deficiency increases amino acid use and impairs muscle function.
Source: American Society for Biochemistry & Molecular Biology (ASBMB)
Lipid sensing by mTOR complexes via de novo synthesis of phosphatidic acid
Source: American Society for Biochemistry & Molecular Biology (ASBMB)
Rat long chain acyl-CoA synthetase 5, but not 1, 2, 3, or 4, complements Escherichia coli fadD.
Source: The University of North Carolina at Chapel Hill University Libraries
CDCP1 drives triple-negative breast cancer metastasis through reduction of lipid-droplet abundance and stimulation of fatty acid oxidation.
Source: Proceedings of the National Academy of Sciences
Coordinate Regulation of the Expression of the Fatty Acid Transport Protein and Acyl-CoA Synthetase Genes by PPARα and PPARγ Activators
Source: Elsevier BV
FATP1 Is an Insulin-Sensitive Fatty Acid Transporter Involved in Diet-Induced Obesity
Source: American Society for Microbiology
A third MRX family (MRX68) is the result of mutation in the long chain fatty acid-CoA ligase 4 (FACL4) gene: proposal of a rapid enzymatic assay for screening mentally retarded patients.
Source: BMJ
Lack of Mitochondrial Anionic Phospholipids Causes an Inhibition of Translation of Protein Components of the Electron Transport Chain A YEAST GENETIC MODEL SYSTEM FOR THE STUDY OF ANIONIC PHOSPHOLIPID FUNCTION IN MITOCHONDRIA
Source: Elsevier BV
FATP1 channels exogenous FA into 1,2,3-triacyl-sn-glycerol and down-regulates sphingomyelin and cholesterol metabolism in growing 293 cells
Source: Elsevier BV
Association of acyl-CoA synthetase-1 with GLUT4-containing vesicles.
Source: Elsevier BV
Targeted deletion of fatty acid transport protein-4 results in early embryonic lethality.
Source: Elsevier BV
Acyl-CoA synthetase isoforms 1, 4, and 5 are present in different subcellular membranes in rat liver and can be inhibited independently.
Source: American Society for Biochemistry & Molecular Biology (ASBMB)
Novel Acyl-CoA Synthetase in Adrenoleukodystrophy Target Tissues
Source: Elsevier BV
Role of long-chain fatty acyl-CoA esters in the regulation of metabolism and in cell signalling.
Source: Portland Press Ltd.
Expression and Characterization of Recombinant Rat Acyl-CoA Synthetases 1, 4, and 5 SELECTIVE INHIBITION BY TRIACSIN C AND THIAZOLIDINEDIONES
Source: American Society for Biochemistry & Molecular Biology (ASBMB)
Fatty acid metabolism in adipocytes: functional analysis of fatty acid transport proteins 1 and 4.
Source: American Society for Biochemistry & Molecular Biology (ASBMB)
Quercetin decreases the triglyceride content through the PPAR signalling pathway in primary hepatocytes of broiler chickens
Source: Informa UK Limited
Identification of the Major Intestinal Fatty Acid Transport Protein
Source: Elsevier BV
Protection against lipoapoptosis of β cells through leptin-dependent maintenance of Bcl-2 expression
Source: Proceedings of the National Academy of Sciences
Acyl-CoA synthetases: fatty acid uptake and metabolic channeling.
Source: Springer Science and Business Media LLC

Linking provided by 

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.