Apolipoprotein M: structure and function

Björn DahlbäckDepartment of Laboratory Medicine, Clinical Chemistry, Wallenberg LaboratoryLund University, Entrance 46,Floor 6, University Hospital, Malmö, S-20502MalmöSweden, Tel.: +46 40 331 501 Fax.: +46 40 337 044 E-mail: [email protected]Correspondence[email protected]

, MD,PhD,

Josefin AhnströmDepartment of Laboratory Medicine, Clinical Chemistry, Wallenberg LaboratoryLund University, Entrance 46, Floor 6, University Hospital, Malmö, S-20502MalmöSweden, Tel.: +46 40 331 418 Fax.: +46 40 337 044 E-mail: [email protected]Correspondence[email protected]

Christina ChristoffersenDepartment of Clinical BiochemistryUniversity of Copenhagen, KB3011, Rigshospitalet,Blegdamsvej 9, DK-2100CopenhagenDenmark, Tel.: +45 3545 2304 Fax.: +45 3545 2524 E-mail: [email protected]Correspondence[email protected]

, MD,PhD &

Lars Bo NielsenDepartment of Clinical BiochemistryUniversity of Copenhagen, Department of Biomedical Sciences, KB3011, Rigshospitalet, Blegdamsvej 9 and DK-2100CopenhagenDenmark, Tel.: +45 3545 2304 Fax.: +45 3545 2524 E-mail: [email protected]Correspondence[email protected]

, MD,PhD

Abstract

Lipoproteins in blood play an important physiological role transporting cholesterol,lipids and lipid-soluble substances to the different organs of the body. Diseases such as atherosclerosis, cardio vascular disease and stroke are associated with defects in lipo protein metabolism. For many years, intense research has focused onthe role of cholesterol in development of atherosclerosis. Cholesterol is transported in both LDL and HDL; increased concentrations of LDL-C are associated with atherosclerosis, whereas high HDL-C isconsidered to be protective against development of atherosclerosis. Apolipoproteins AI and Bare the major proteins of HDL and LDL,respectively. In HDL, a large number of additional proteins with important functions have been identified. A late addition to thelist of HDL-associated proteins isapoM, the structure and function of which are the topicof this review.

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