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Abstract
Objective
To examine monocyte chemotactic protein-1 (MCP-1) concentration and future rheumatoid arthritis (RA) risk, and investigate effect modification by human leukocyte antigen-shared epitope (HLA-SE) and several lifestyle factors.
Methods
We conducted a nested case–control study using stored plasma samples from the Nurses’ Health Studies. Each pre-RA case was matched to three controls (Ncase= 220, Ncontrol = 675). Odds ratios (OR) for RA associated with MCP-1 concentration and interactions with HLA-SE, smoking, BMI and alcohol intake were estimated.
Results
MCP-1 concentration was associated with both seropositive and seronegative RA, in particular <5 years of blood draw (OR: 2.42), and among HLA-SE positive (OR: 2.05). No interactions with smoking, BMI or alcohol were detected.
Conclusion
MCP-1 was associated with risk of RA, especially among HLA-SE positive, but did not differ by smoking status, BMI or alcohol intake.
Financial & competing interests disclosure
The authors declare that they have no conflicts of interests. This work was supported by the NIH (grants CA186107, CA49449, CA176726, CA67262, AR59073, AR066109, AR49880, AR52403, AR047782) and a doctoral dissertation award from the Arthritis Foundation. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.
No writing assistance was utilized in the production of this manuscript.