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Abstract
Aim: Granzyme B could induce apoptosis of target cell in acute myocardial infarction (AMI) and was identified as the target of miR-874-3p by searching the miRNA database. We aim to determine the levels of granzyme B and miR-874-3p as well as assay their correlations or predict powers in AMI. Patients & methods: We measured levels of plasma granzyme B and miR-874-3p in 80 AMI patients or 40 healthy controls and assayed their correlations or predicted powers for AMI. Results: Elevated levels of granzyme B (16.71 ± 7.23 ng/l vs 9.27 ± 3.90 ng/l) correlated with miR-874-3p downregulation (0.20- ± 0.17-fold vs 1.00- ± 0.79-fold) in AMI patients. Conclusion: Plasma miR-874-3p might target granzyme B and it might be an additional biomarker for AMI.
Financial & competing interests disclosure
This study was supported by the National Natural Science Foundation of China (C0805). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.
No writing assistance was utilized in the production of this manuscript.
Ethical conduct of research
The Ethics Committee of Jilin University Second Hospital approved the protocol of this study and the principles of the Declaration of Helsinki [Citation22]. Written consent was obtained from all subjects.