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Abstract
Aim: To determine the effect of the 21-gene recurrence score (RS) on outcome and chemotherapy decision in breast invasive lobular carcinoma (ILC). Materials & methods: We included 6467 patients with early stage and estrogen receptor–positive ILC from the Surveillance, epidemiology, and end results database. Results: A total of 9.1, 31.4, and 70.1% of patients with low-, intermediate-, and high-risk RS groups received chemotherapy, respectively. A higher RS was independently associated with poor breast cancer-specific survival, and receipt of chemotherapy was not related to better breast cancer-specific survival in low-, intermediate-, or high-risk RS groups. Conclusion: The 21-gene RS could impact chemotherapy decision making in early-stage ILC. However, adjuvant chemotherapy does not appear to improve outcome in high-risk RS cohort.
Financial & competing interests disclosure
This work was partly supported by the National Natural Science Foundation of China (81872459, 81803050), Natural Science Foundation of Fujian Province (No. 2016J01635), Natural Science Foundation of Guangdong Province (No. 2018A030313666) and the Science and Technology Planning Projects of Xiamen Science & Technology Bureau (No. 3502Z20174070). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.
No writing assistance was utilized in the production of this manuscript.
Ethical conduct of research
Analysis of data from SEER is exempted from Institutional Review Board approval since the database contains only de-identified information of patients.