Neural Activities Are Unfavorable for the Prognosis of Ovarian Cancer Through Mrna Expression Analysis

Abstract

Aim: Ovarian cancer (OC) is the leading lethal gynecological cancer in women worldwide. Understanding the molecular mechanism of OC is very important for the identification of highly sensitive biomarkers for its prognosis. Methodology: We detected prognostic-related mRNA of OC in OncoLnc database. The main features between the unfavorable and favorable prognostic OC mRNAs were analyzed and Kyoto Encyclopedia of Genes and Genomes pathway enrichment as well as correlation analysis was conducted in our study. Conclusion: Our findings suggest that neural activities can promote OC progression, indicating poor prognosis, among which axon guidance functions most significantly govern the main neural activities, followed by neurogenesis and angiogenesis. Four neural genes (NTN1, UNC5B, EFNB2 and EFNA5) could serve as promising biomarkers and therapeutic targets for precision medicine to treat OC patients.

Keywords:

• axon guidance
• biomarkers
• neural activity
• ovarian cancer
• prognosis

Supplementary data

To view the supplementary data that accompany this paper please visit the journal website at: www.tandfonline.com/doi/suppl/10.2217/bmm-2019-0056

Financial & competing interests disclosure

The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.

No writing assistance was utilized in the production of this manuscript.

Acknowledgements

The authors would like to thank all of the researchers who provided their data and analysis tools for this manuscript.

Availability of data & materials

All the data in the present study were downloaded from the OncoLnc website.

Ethical conduct of research

All the data in the present study were downloaded from the OncoLnc database (the original ovarian cancer mRNA information was from TCGA). The National Cancer Institute (NCI) and the National Human Genome Research Institute (NHGRI) ensure that this study was well designed, legal and ethical and that it did not involve unnecessary risks to patients.

Author contributions

Conceptualization is done by Y Yue, L Yang and L Bie; L Yang, L Bie, L Sun and Y Yue contributed in formal analysis and writing – review and editing; L Yang, L Bie and L Sun contributed in methodology and visualization; supervision is done by Y Yue; and L Yang contributed in writing – original draft.