Urinary Excretion of Liver-Type FABP as a New Clinical Marker for the Progression of Obstructive Nephropathy

Abstract

Aim: The aim of this article was to investigate the performance and predictive value of urinary liver-type FABP (uL-FABP) and urinary NGAL (uNGAL) for renal function and prognosis in obstructive nephropathy (ON). Patients & methods: A total of 108 ON patients and urine samples were collected. An ELISA was used to determine the uL-FABP and uNGAL levels. A total of 90 patients completed the 1-year follow-up and were used to evaluate the predictive value of uL-FABP and uNGAL for the renal prognosis in ON. Results: During the 1-year renal function follow-up, the uL-FABP level was significantly correlated with poor prognosis. When the preoperative uL-FABP and uNGAL or 72-h postoperative uL-FABP and uNGAL levels were combined, the areas under the curve for renal prognosis were 0.968 and 0.952, respectively. Conclusion: uL-FABP was helpful for the prediction of renal prognosis in ON. The combination of uL-FABP and uNGAL increased the accuracy of prediction.

Keywords::

• acute kidney injury
• combined markers
• diagnosis
• Kaplan–Meier method
• liver-type FABP
• NGAL
• obstructive nephropathy
• receiver operating characteristic–area under the curve
• renal prognosis
• urinary marker

Financial & competing interests disclosure

This study was supported in part by the National Basic Research Program of China 973 Program No. 2012CB517600 (No. 2012CB517602) and HongKong, Macao and Taiwan Science & Technology Cooperation Program of China (2014DFT30090). The study was also sponsored by the National Natural Science Foundation of China (81102700, 81373865) and by grants 12401906400 and 13401906100 from the Science and Technology Commission of Shanghai Municipality, China and ZYSNXD012-RC-ZXY017 from the Shanghai Health Bureau. A funding scheme for training young teachers in colleges and universities in Shanghai was also included in the fund. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

No writing assistance was utilized in the production of this manuscript.

Ethical conduct of research

The authors state that they have obtained appropriate insti-tutional review board approval or have followed the princi-ples outlined in the Declaration of Helsinki for all human or animal experimental investigations. In addition, for investi-gations involving human subjects, informed consent has been obtained from the participants involved.

Additional information

Funding

This study was supported in part by the National Basic Research Program of China 973 Program No. 2012CB517600 (No. 2012CB517602) and HongKong, Macao and Taiwan Science & Technology Cooperation Program of China (2014DFT30090). The study was also sponsored by the National Natural Science Foundation of China (81102700, 81373865) and by grants 12401906400 and 13401906100 from the Science and Technology Commission of Shanghai Municipality, China and ZYSNXD012-RC-ZXY017 from the Shanghai Health Bureau. A funding scheme for training young teachers in colleges and universities in Shanghai was also included in the fund. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.