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Clinical Lipidology Volume 6, 2011 - Issue 1
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Perivascular adipose tissue and vascular disease

Kathryn BrittonNational Heart, Lung & Blood, Institute’s Framingham Heart Study, Framingham, MA, USA;Division of Cardiovascular Medicine, Brigham & Women’s Hospital & Harvard Medical School, Boston, MA, USA
&
Caroline FoxNational Heart, Lung & Blood, Institute’s Framingham Heart Study, Framingham, MA, USA;2National Heart, Lung & Blood Institute & the Center for Population Studies, Framingham, MA, USA;Division of Endocrinology, Metabolism & Hypertension, Brigham & Women’s Hospital & Harvard Medical School, Boston, MA,, USACorrespondence[email protected]
Pages 79-91 | Published online: 18 Jan 2017
 
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Abstract

Perivascular adipose tissue is a local deposit of adipose tissue surrounding the vasculature. Perivascular adipose tissue is present throughout the body and has been shown to have a lo al effect on blood vessels. The influence of perivascular adipose tissue on the vasculature changes with increasing adiposity. This article describes the anatomy and pathophysiology of p ivascular adipose tissue and the experimental evidence supporting its local adverse effect on the vasculature. Methods for quantifying perivascular adipose tissue in free-living populationswill be described. Finally, the epidemiological literature demonstrating an association between perivascular adipose tissue and cardiometabolic disease will be explored.

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