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Clinical Lipidology Volume 7, 2012 - Issue 2
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Regulation of lipid metabolism in breast cancer provides diagnostic and therapeutic opportunities

Mika Hilvo Mika HilvoBiotechnology for Health & Well-being, VTT Technical Research Centre of Finland, PO Box 1000, FI-02044 VTT, Espoo, FinlandCorrespondence[email protected]
&
Andreas Matej Orešiè Mika HilvoBiotechnology for Health & Well-being, VTT Technical Research Centre of Finland, PO Box 1000, FI-02044 VTT, Espoo, Finland
Pages 177-188 | Published online: 18 Jan 2017
 
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Abstract

During malignant transformation, the lipid metabolism of cells changes radically and therefore alterations in lipid metabolism are a prominent feature of solid tumors. Lipid metabolism has been investigated at the gene and protein expression levels for several decades, but recent advances in lipidomics technology have also enabled the investigation of pathways at the level of molecular lipids. This review provides an overview of the changes of global lipid metabolism (i.e., fatty acid, phospholipid, eicosanoid and sphingolipid metabolism) in breast cancer, and discusses the diagnostic and therapeutic potential of these pathways.

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