HDL functionality in diabetes mellitus: potential importance of glycation

Abstract

The incidence of atherosclerotic cardiovascular diseases correlates negatively with HDL. HDL has multiple potentially antiatherogenic properties that may be impaired in diabetes mellitus; in partciular, glycation of HDL could render it functionally deficient. This review explores the possible atheroprotective properties of HDL, the effect of diabetes mellitus and glycation on these properties and therapeutic interventions which could potentially reverse unfavorable deficiencies in HDL functionality.

Keywords::

• cholesteryl ester transfer protein
• diabetes mellitus
• dysfunctional HDL
• glycation
• HDL
• lecithin:cholesterol acyl transferase
• PON 1