Serum amyloid A concentration may reflect HDL functionality

Abstract

Evaluation of: Dullaart RP, de Boer JF, Annema W, Tietge UJ. The inverse relation of HDL anti–oxidative functionality with serum amyloid A is lost in metabolic syndrome subjects. Obesity 21, 361–366 (2013). Antiatherogenic functions exerted by HDLs are impaired in coronary heart disease and other pathologic conditions associated with increased cardiovascular risk; however, the direct assessment of HDL functionality is challenging. In the evaluated study, Dullaart et al. report the inverse association between plasma serum amyloid A (SAA) concentrations and the capacity of HDL to inhibit LDL oxidation in healthy individuals, but notinpatientswithmetabolicsyndrome.ThesefindingsprovidethefirstindicationthatSAAdeterminationmight be helpful as an indirect measure for the antioxidative capacity of HDL. However, the utility of SAA measurement as a proxy for HDL functionality may be limited to certain populations.

Key Words:

• antioxidative capacity
• HDL
• metabolic syndrome
• serum amyloid A