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Abstract
Aim: Sideritis euboea is used to prepare a widely consumed beverage. We evaluated the biological activity of S. euboea in healthy human subjects, focusing on serum cardiovascular factors, including lipids, inflammation and glucose homeostasis markers. Patients & methods: In a double-blind study, 54 participants were randomly assigned to consume S. euboea aqueous extract food (n = 27, intervention group) or a placebo food (n = 27, control group) for a 1-month period. A total of 47 participants were included in the final ana lysis. Serum lipids (total cholesterol, HDL cholesterol, LDL cholesterol, triglycerides, lipoprotein lipase(a)), Homeostasis Model Assessment and inflammatory markers were determined. Results: Total cholesterol was reduced significantly in the intervention group, while no beneficial effects on other lipid parameters and inflammatory markers were observed. In females, S. euboea significantly ameliorated the Homeostasis Model Assessment index. Conclusion: The consumption of S. euboea induces only a significant total cholesterol lowering effect while it exerts insulin-sensitizing actions in females. Larger studies with a longer intervention period should be performed.