Diet and lifestyle interventions on lipids: combination with genomics and metabolomics

Abstract

Lipids have been closely related to risk of a variety of metabolic disorders such as cardiovascular disease and diabetes. Compelling evidence has shown that diet/lifestyle interventions may affect circulating lipid profile; research in genetics has associated more than 150 common variants with lipid traits. In recent years, emerging data from observational studies and randomized clinical trials have shown that dietary and lifestyle factors might interact with genetic factors in determining lipid levels. In addition, the emerging ‘omics’ research, especially lipidomics, owns potentials to provide comprehensive insights into the mechanisms underlying gene–diet/lifestyle interactions. Although many challenges exist, studies in these areas hold promise to inform future personalized diet and lifestyle interventions on improvement of lipids and mitigate the related disorders.

Keywords:

• dietary intervention
• gene–environment interaction
• genetics
• lifestyle intervention
• lipidomics
• personalized medicine