Circular RNA Hsa_Circ_0000993 Inhibits Metastasis of Gastric Cancer Cells

Abstract

Aim: We aimed to explore the roles of circRNAs in gastric cancer. Materials & methods: The dysregulated circRNAs and miRNAs were identified using data from Gene Expression Omnibus. The roles of specifically selected circRNAs were explored. Survival analysis was performed using data from the Cancer Genome Atlas. Results: We identified 68 dysregulated circRNAs and 51 dysregulated miRNAs. We found that hsa_circ_0000993 inhibited migration, invasion and proliferation of gastric cancer cells and could act as a miRNA sponge for miR-214-5p but did not modulate expression of its parental gene, ATL2. Survival analysis showed that gastric cancer patients with lowly expressed miR-214-5p had a significantly better overall survival. Conclusion: In conclusion, hsa_circ_0000993 may inhibit metastasis of gastric cancer through sequestering miR-214-5p.

Keywords::

• ATL2
• circular RNA
• invasion
• metastasis
• microRNA
• migration
• prognosis
• proliferation
• stomach carcinoma
• survival

Supplementary data

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Financial & competing interests disclosure

This study was funded by the National Natural Science Foundation of China (grant number 81602551) and the young talents program of Jiangsu Cancer Hospital (grant number 2017YQL-10). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

No writing assistance was utilized in the production of this manuscript.

Ethical conduct of research

This article does not contain any studies with human participants or animals performed by any of the authors.

Additional information

Funding

This study was funded by the National Natural Science Foundation of China (grant number 81602551) and the young talents program of Jiangsu Cancer Hospital (grant number 2017YQL-10). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. No writing assistance was utilized in the production of this manuscript.