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Abstract
Endocrine-disrupting compounds (EDCs) are a broad class of chemicals present in many residential products that can disrupt hormone signaling and cause health problems in humans. Multigenerational cohorts, like the Michigan polybrominated biphenyl registry, are ideal for studying the effects of intergenerational exposure. Registry participants report hormone-related health problems, particularly in those exposed before puberty or those in the second generation exposed through placental transfer or breastfeeding. However, more research is needed to determine how EDCs cause health problems and the mechanisms underlying intergenerational exposure. Utilizing existing data in this registry, along with genetic and epigenetic approaches, could provide insight to how EDCs cause human disease and help to determine the risk to exposed populations and future generations.
Acknowledgements
We are grateful to the members of the Michigan PBB registry for their participation and engagement with research studies over the past 40 years.
Financial & competing interests disclosure
This work was supported by the National Institute of Environmental Health Sciences (NIEHS; 5R01ES024790, 5R01ES025775) and the National Institute of General Medical Sciences (T32GM008490). The authors declare they have no actual or potential competing financial interest. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. No writing assistance was utilized in the production of this manuscript.