Uncovering Novel Landscape of Cardiovascular Diseases and Therapeutic Targets for Cardioprotection Via Long Noncoding RNA–miRNA–mRNA Axes

Abstract

Protein coding sequences account for around 3% of the human genome, the rest are noncoding RNA (ncRNA) including long ncRNA (lncRNA) and miRNA. Accumulating evidence indicates that lncRNAs and miRNAs are candidate biomarkers for diagnosis, prognosis and therapy of cardiovascular diseases. The lncRNAs act as sponge-like effects on numerous miRNAs, subsequently regulating miRNAs and their targets, mRNA functions. The role of lncRNA–miRNA–mRNA axis in pathogenesis of cardiovascular diseases has been recently reported and highlighted. Herein, this review discusses emerging roles of lncRNA–miRNA–mRNA axis in cardiovascular pathophysiology and regulation, with a novel focus on cardioprotective network activities of the two subgroup ncRNAs.

Keywords::

• apoptosis
• atherosclerosis
• autophagy
• ceRNA
• endothelial cells
• necrosis

Acknowledgements

We thank those members of our laboratories for their support and critically reading of this review.

Financial & competing interests disclosure

This work was supported by the National Natural Science Foundation of China (81460044 and 81160035), Yunnan Provincial Science and Technology Department (2014HB031 and 2017FE468[-039]) and Yunnan health training project of high level talents. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

No writing assistance was utilized in the production of this manuscript.

Additional information

Funding

This work was supported by the National Natural Science Foundation of China (81460044 and 81160035), Yunnan Provincial Science and Technology Department (2014HB031 and 2017FE468[-039]) and Yunnan health training project of high level talents. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. No writing assistance was utilized in the production of this manuscript.