https://orcid.org/0000-0001-8870-515X
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Abstract
Aim: Altered long noncoding RNA (lncRNA) and mRNA is vital in the progression from Helicobacter pylori (H. pylori, HP) infection to gastric cancer (GC) and mucosa-associated lymphoid tissue (MALT) lymphoma. Materials & methods: Five independent Gene Expression Omnibus datasets (GSE5081, GSE84433, GSE15459, GSE66229 and GSE25638) were included in our study. Results: Differentially expressed lncRNAs and mRNAs in both H. pylori-positive gastritis and GC tissues were identified. Using two GC cohorts, the H. pylori-related mRNA DYNC1I1 and MMP7 were independent predictors of overall survival. Moreover, the expressions of lncRNA GHRLOS and 44 mRNAs were significantly changed in gastric MALT lymphoma patients. Conclusion: The lncRNA/mRNA response to H. pylori infection in gastritis and GC influence the outcome of GC and progression of MALT lymphoma.
Author contributions
J Zhang and JM Wei performed the experiments. J Zhang, JM Wei, ZX Wang, Y Feng, ZW Wei, JB Xun, X Hou, YL He and DJ Yang analyzed the data. J Zhang and JM Wei wrote the manuscript. J Zhang conceived and designed the experiments. All authors read and approved the final manuscript.
Financial & competing interests disclosure
This work was supported by National Natural Science Foundation of China (No. 81802342, 81672333 and 81702319), Natural Science Foundation of Guangdong (China; No. 2017A030313570). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.
No writing assistance was utilized in the production of this manuscript.