The Inter-Talk Between Mycobacterium Tuberculosis and the Epigenetic Mechanisms

Abstract

Epigenetics regulate gene function without any alteration in the DNA sequence. The epigenetics represent one of the most important regulators in different cellular processes and have initially been developed in microorganisms as a protective strategy. The evaluation of the epigenetic mechanisms is also important in achieving an efficient control strategy in tuberculosis (TB). TB is one of the most significant epidemiological concerns in human history. Despite several in vivo and in vitro studies that have evaluated different epigenetic modifications in TB, many aspects of the association between epigenetics and TB are not fully understood. The current paper is aimed at reviewing our knowledge on histone modifications and DNA methylation modifications, as well as miRNAs regulation in TB.

Keywords: :

• DNA methylation
• epigenetic modification
• histone
• miRNA
• Mycobacterium tuberculosis

Acknowledgments

The authors are grateful to the personnel of Mycobacteriology and Pulmonary Research Department, Pasteur Institute of Iran for their assistance in this project. We tender our apologies to those authors whose deserving research was not cited in this manuscript.

Financial & competing interests disclosure

The current project was supported by grant No. B-9426 from the Pasteur Institute of Iran. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

Writing assistance was utilized in the production of this manuscript.

Additional information

Funding

The current project was supported by grant No. B-9426 from the Pasteur Institute of Iran. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. Writing assistance was utilized in the production of this manuscript.