Methylation Map Genes Can be Critical in Determining the Methylome of Intracranial Aneurysm Patients

Abstract

Aim: Intracranial aneurysm is often asymptomatic until the time of rupture. Elevated homocysteine is reported in vascular diseases. Identifying early events in homocysteine metabolism through methylation map genes may prevent fatality. Materials&methods: In the present study, we investigated the role of variants in methylation map genes in ethnically matched 480 individuals that can influence the homocysteine levels and promote development of aneurysm. Results: The study demonstrates that the genetic variants in folate cycle and methionine cycle genes such as MTHFR, MTRR, MTR, BHMT and DNMT1 are associated with the risk of aneurysm. Conclusion: The associated allelic variants in these genes have functional relevance and are predictive of decreased expression indicative of altered methylation levels that may result in elevated homocysteine.

Keywords::

• aneurysm
• BHMT
• DNMT1
• homocysteine
• methylation
• MTHFR
• MTR
• MTRR

Supplementary data

To view the supplementary data that accompany this paperplease visit the journal website at: www.tandfonline.com/doi/suppl/10.2217/epi-2019-0280

Financial&competing interests disclosure

The authors are thankful to Department of Biotechnology, Govt. of India, for providing the intramural support through RGCB. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

No writing assistance was utilized in the production of this manuscript.

Ethical conduct of research

The authors state that they have obtained appropriate institutional review board approval or have followed the principles outlined in the Declaration of Helsinki for all human or animal experimental investigations. In addition, for investigations involving human subjects, informed consent has been obtained from the participants involved.

Additional information

Funding

The authors are thankful to Department of Biotechnology, Govt. of India, for providing the intramural support through Rajiv Gandhi Centre for Biotechnology (RGCB). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. No writing assistance was utilized in the production of this manuscript.