Circular RNA: Biogenesis, Degradation, Functions and Potential Roles in Mediating Resistance to Anticarcinogens

Abstract

Aim: This review aims to systematically describe the biogenesis and degradation of circular RNAs (circRNAs), discusses the major functions of circRNAs, introduces the mechanisms by which circRNAs play a role in cancer, comprehensively summarize the relationship between circRNAs and anticarcinogen resistance as well as underlying specific mechanisms in multiple cancers. Materials & methods: We screened and analyzed large quantity of scientific papers which associated with circRNAs, noncoding RNAs, function, cancer, drug resistance and chemoresistance, and then summarized in Figures 1 & 2 & Table 1. Results & conclusion: The biogenesis, degradation and function of circRNAs are specially compared with other noncoding RNAs, it can affect cancer pathogenesis and progression and are implicated in mediating resistance to various anticarcinogens in various types of cancer.

Keywords::

• anticarcinogens
• biogenesis
• cancer
• circRNA
• circular RNA
• degradation
• drug resistance
• function
• mechanism
• noncoding RNA

author-contributions

XC Geng and YC Jia were the major contributors to the writing and revision of the manuscript. YH Zhang, L Shi and Q Li collected the related references and participated in discussions. All authors read and approved the final manuscript.

Financial & competing interest disclosure

This work was financially supported by grants from the government-funded Provincial Clinical Medicine Talent Programs in 2017; Science and Technology Capacity Improvement Projects of Hebei University of Chinese Medicine in 2019 (no. KTZ2019019); Outstanding Student Scientific Research Ability Improvement Projects of Hebei University of Chinese Medicine in 2019 (no. YXZ2019002); Graduate Innovative Ability Training Projects of Hebei Province in 2020. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

This paper was edited for proper English language, grammar, punctuation, spelling and overall style by one or more of the highly qualified native English-speaking editors at American Journal Experts. This certificate was issued on 28 September 2019 and may be verified on the American Journal Experts website using the verification code 1FB2-171E-2B93-202F-117P.

Additional information

Funding

This work was financially supported by grants from the government-funded Provincial Clinical Medicine Talent Programs in 2017; Science and Technology Capacity Improvement Projects of Hebei University of Chinese Medicine in 2019 (no. KTZ2019019); Outstanding Student Scientific Research Ability Improvement Projects of Hebei University of Chinese Medicine in 2019 (no. YXZ2019002); Graduate Innovative Ability Training Projects of Hebei Province in 2020. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. This paper was edited for proper English language, grammar, punctuation, spelling and overall style by one or more of the highly qualified native English-speaking editors at American Journal Experts. This certificate was issued on 28 September 2019 and may be verified on the American Journal Experts website using the verification code 1FB2-171E-2B93-202F-117P.