Identification of CDC5L as Bridge Gene Between Chronic Obstructive Pulmonary Disease and Lung Adenocarcinoma

Abstract

Aim: This study aimed to explore the genetic and epigenetic similarities between chronic obstructive pulmonary disease (COPD) and lung adenocarcinoma (LUAD). Materials & methods: We mainly used Weighted correlation network analysis, protein–protein interaction network and pivot analysis to identify hub modules, bridge regulators, bridge genes and hub-driving genes in both diseases and carried out verifying using external datasets. Results: We identified eight bridge regulators, 19 key molecules in the COPD model and ten key molecules in the LUAD model. Moreover, we validated that CDC5L could be a reliable biomarker in COPD and may regulate cell proliferation and metastasis in LUAD via promoter methylation. Conclusion: Our results might form a theoretical foundation for future study at an epigenetic level.

Keywords::

• biomarker
• cancer metastasis
• cancer proliferation
• CDC5L
• chronic obstructive pulmonary disease
• epigenetics
• lung adenocarcinoma
• methylation
• the Cancer Genome Atlas
• transcription factors

Supplementary data

To view the supplementary that accompanies this paper, please view the journal website at: www.tandfonline.com/doi/suppl/10.2217/epi-2020-0112

Financial & competing interests disclosure

This study was partially sponsored by grants from the National Natural Science Foundation of China (no. 81672866, 81560452 and 81960501 to X-B Lv, no. 81660391 to B-T Yu); the Natural Science Foundation of Jiangxi Province (no. 20161BAB205192 and 20171ACB21073 to X-B Lv); Excellent Youth Foundation of Jiangxi Scientific Committee (no. 20162BCB23001 to X-B Lv); The Foundation of Nanchang Science and Technology Bureau (no. 2016 ZSCX009 to X-B Lv); grant 2019HXFH069 from 1·3·5 project for disciplines of excellence–Clinical Research Incubation Project, West China Hospital, Sichuan University; grant 20YYJC3337 from Science and Technology Department of Sichuan Province to L Ye. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

Information pertaining to writing assistance

The authors would like to thank Enago (www.enago.cn) for the writing assistance under the sponsored Grant 20YYJC3337 from Science and Technology Department of Sichuan Province.

Additional information

Funding

This study was partially sponsored by grants from the National Natural Science Foundation of China (no. 81672866, 81560452 and 81960501 to X-B Lv, no. 81660391 to B-T Yu); the Natural Science Foundation of Jiangxi Province (no. 20161BAB205192 and 20171ACB21073 to X-B Lv); Excellent Youth Foundation of Jiangxi Scientific Committee (no. 20162BCB23001 to X-B Lv); The Foundation of Nanchang Science and Technology Bureau (no. 2016 ZSCX009 to X-B Lv); grant 2019HXFH069 from 1·3·5 project for disciplines of excellence–Clinical Research Incubation Project, West China Hospital, Sichuan University; grant 20YYJC3337 from Science and Technology Department of Sichuan Province to L Ye. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.