The Growing Landscape of Succinylation Links Metabolism and Heart Disease

Abstract

Post-translational modification of proteins is an important biochemical process that occurs at the protein level. Succinylation is a newly discovered post-translational modification with the hallmark of a significant chemical and structural change. Succinylation has many similarities with other modifications, but succinylation may lead to more functional changes. Although the physiological significance of succinylation has not been well characterized, the lysine succinylation modification shows great potentials during disease processes. The discovery of SIRT5 has made great progress in exploring the role of succinylation in energy metabolism, heart disease and tumorigenesis. In this review, we focus on the discovery of succinylation in organisms and mechanism of succinylation. We are also concerned with the metabolic reactions and heart diseases associated with succinylation.

Keywords::

• heart disease
• lysine succinylation
• metabolism
• SIRT5
• succinyl-CoA
• succinyltransferase

Author contributions

LT Yang and S Miao collected the related papers. LT Yang and PY Wang drafted and wrote the manuscript. JX Wang design and revised the manuscript. GL Liu and J Zhang helped to draft and revise the manuscript. All authors read and approved the final manuscript.

Financial & competing interests disclosure

This work was supported by Natural Science Foundation of Shandong Province (JQ201815, ZR2019ZD28). Technology program of Qingdao City (18-6-1-80-nsh). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

Writing assistance was utilized in the production of this manuscript from Scribendi. Funding was obtained from the support mentioned above.

Additional information

Funding

This work was supported by Natural Science Foundation of Shandong Province (JQ201815, ZR2019ZD28). Technology program of Qingdao City (18-6-1-80-nsh). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. Writing assistance was utilized in the production of this manuscript from Scribendi. Funding was obtained from the support mentioned above.