Abstract
Aim & methods: Non-exosomal and exosomal ncRNAs have been reported to be involved in the regulation of coronary artery disease (CAD). Therefore, to explore the biological effects of non-exosomal/exosomal ncRNAs in CAD, the authors searched for studies published in the last 3 years on these ncRNAs in CAD and summarized their functions and mechanisms. Results: The authors summarized 120 non-exosomal ncRNAs capable of regulating CAD progression. In clinical studies, 47 non-exosomal and nine exosomal ncRNAs were able to serve as biomarkers for the diagnosis of CAD. Conclusion: Non-exosomal/exosomal ncRNAs are not only able to serve as biomarkers for CAD diagnosis but can also regulate CAD progression through ceRNA mechanisms and are a potential target for early clinical intervention in CAD.
Plain language summary
ncRNAs are increasingly found to play regulatory roles in coronary artery disease (CAD), and transcriptome studies offer greater advantages for controlling CAD at its source. Therefore, the authors conducted an accurate search and summary of studies on CAD and ncRNAs published in the past 3 years to analyze the main pathological mechanisms in CAD progression, aiming to provide a research basis for clinical treatment of CAD.
Supplementary data
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Author contributions
L Wang, J Fu, Y Peng and P Yang were responsible for the conception and design of the study. P Ding, S Lu and L Zhang provided learning materials for the study. H Ma and G Sun collected and organized the data. J Li and X Wu were responsible for data analysis and interpretation. L Wang, J Fu and P Yang provided administrative support for the study. All authors participated in the writing and final review of the manuscript.
Financial & competing interests disclosure
This study was supported by the National Natural Science Foundation of China (81860073, 81760074, 81860265), Special Foundation Projects of Joint Applied Basic Research of Yunnan Provincial Department of Science and Technology with Kunming Medical University (2019FE001[-138]), Yunnan Provincial Department of Science and Technology (202001AT070039), Yunnan Health Training Project of High Level Talents (H-2018032), 100 Young and Middle-Aged Academic and Technical Backbones of Kunming Medical University (60118260106), Young Talents of Yunnan Thousand Talents Plan (RLQN20200002), Graduate Student Innovation Fund of Kunming Medical University (2022S035) and Clinical Medical Center for Cardiovascular and Cerebrovascular Disease of Yunnan Province (ZX2019-03-01). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.
No writing assistance was utilized in the production of this manuscript.