There’s More to it: Uncovering Genomewide DNA Methylation Heterogeneity

Tweetable abstract

Monitoring changes in methylation heterogeneity can be powerful in detecting disease progression early. This editorial highlights the importance of profiling methylation heterogeneity and identifies existing measures and research gaps.

Keywords::

• bulked methylome
• entropy
• epialleles
• epigenomics
• heterogeneity
• methylation

Financial & competing interests disclosure

This work was supported by grants from Academia Sinica and the Ministry of Science and Technology of Taiwan (111-2311-B-001-030- and 109-2313-B-001-009-MY3); VGH-TSGH-AS Joint Research Program (VTA112-T-3-2) and NTU-AS Innovative Joint Program (AS-NTU-112-12) to P Chen. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

No writing assistance was utilized in the production of this manuscript.

Additional information

Funding

This work was supported by grants from Academia Sinica and the Ministry of Science and Technology of Taiwan (111-2311-B-001-030- and 109-2313-B-001-009-MY3); VGH-TSGH-AS Joint Research Program (VTA112-T-3-2) and NTU-AS Innovative Joint Program (AS-NTU-112-12) to P Chen. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. No writing assistance was utilized in the production of this manuscript.