Tweetable abstract
MeCP2 is an epigenetic factor with global impact in epigenome integrity, membrane-less nuclear architecture, and chromatin stability. Our Editorial covers recent advances on these important topics.
Graphical abstract
MeCP2 binding to unmethylated DNA may prevent DNA methyl transferases (DNMT) binding to DNA, inhibiting 5-methylcytosine (5mC) formation. MeCP2 binding to 5mC can prevent ten-eleven translocation (TET) binding and 5-hydroxymethylcytosine (5hmC) formation. Figure created with BioRender.com with our own design.
Financial disclosure
This work is supported by funding from the Natural Sciences and Engineering Research Council of Canada (NSERC) Discovery Grant RGPIN-2016-06035 and University of Manitoba NSERC Bridge Funding (to MR). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.
Competing interests disclosure
The authors have no competing interests or relevant affiliations with any organization or entity with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.
Writing disclosure
No writing assistance was utilized in the production of this manuscript.