Low Expression Levels of miRNA-155 and miRNA-499a are Associated with Obesity in Type 2 Diabetes

Abstract

Background & aims: This study investigated a possible correlation between three circulating miRNAs, previously observed to be associated to diabetic polyneuropathy, and the obesity condition. Methods & results: The expression levels of miR-128a, miR-155 and miR499a were evaluated in 49 participants with Type 2 diabetes, divided into different groups based on the presence or absence of obesity and central obesity. The analyses revealed a significant decrease of miR-155 and miR-499a expression levels in obese subjects. In particular, the reduction appears to be even more significant in Type 2 diabetes subjects with central obesity. Conclusion: The results suggest that these miRNAs could be involved in obesity-driven pathogenetic mechanisms.

Keywords::

• microRNA
• miR-155
• miR-499a
• obesity
• Type 2 diabetes

Supplementary data

To view the supplementary data that accompany this paper please visit the journal website at: www.futuremedicine.com/doi/suppl/10.2217/epi-2023-0320

Author contributions

Conceptualization: P Borgiani, C Ciccacci; data curation: A Latini, G De Benedittis; formal analysis: A Latini, G De Benedittis; funding acquisition: G Novelli; investigation: A Latini, G De Benedittis; methodology: A Latini, G De Benedittis; project administration: G Novelli; resources: V Spallone; supervision: V Spallone, P Borgiani; validation: C Ciccacci; roles/writing – original draft: A Latini; writing – review and editing: C Ciccacci, V Spallone, P Borgiani.

Financial disclosure

This study was supported by a grant of “Piano Sviluppo e Coesione Salute” (FSC 2014-2020. T3-AN-04 GENERA) and by a grant of European Union – NextGenerationEU, PNRR M4-C2-1.4 (CN00000041) to G Novelli. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

Competing interests disclosure

The authors have no competing interests or relevant affiliations with any organization or entity with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending or royalties.

Writing disclosure

No writing assistance was utilized in the production of this manuscript.

Ethical conduct of research

The authors state that they have obtained appropriate institutional review board approval or have followed the principles outlined in the Declaration of Helsinki for all human or animal experimental investigations. All participants provided written informed consent. The study was approved by the Ethics Committee of the University Hospital of Rome Tor Vergata (approval no. 2936/2017).

Data sharing statement

Data will be made available on request.

Additional information

Funding

This study was supported by a grant of “Piano Sviluppo e Coesione Salute” (FSC 2014-2020. T3-AN-04 GENERA) and by a grant of European Union – NextGenerationEU, PNRR M4-C2-1.4 (CN00000041) to G Novelli. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.