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Abstract
“Although the epigenetic silencing by promoter hypermethylation and histone modifications is a well-known hallmark of many tumor suppressor genes, the majority of genes silenced by these epigenetic events in cancer cells could be passengers, not drivers, during tumor initiation and progression. Therefore, these silenced genes should be further investigated by analyzing their genetic lesions in tumor cells and functions in normal cells””
Financial & competing interests disclosure
The author has no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.
No writing assistance was utilized in the production of this manuscript.