Targeting Chromatin in Fungal Pathogens as A Novel Therapeutic Strategy: Histone Modification Gets Infectious

Abstract

“Compelling evidence suggests that inhibiting chromatin-related processes may strongly impact fungal virulence.”

KEYWORDS::

• antifungal drug discovery
• chromatin modification
• epigenetics
• fungal pathogens
• immune evasion
• pathogenesis

Acknowledgements

The authors would like to apologize to colleagues who have contributed to this emerging field, yet whose work they were unable to cite owing to space constraints.

Financial & competing interests disclosure

Work in the authors‘ laboratory has been funded by grants from the Christian Doppler Research Society by the Austrian Science Foundations (FWF and FFG), and in part by the Vienna Biocenter PhD Program WK001 (to Denes Hnisz, and Michael Tscherner). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.

No writing assistance was utilized in the production of this manuscript.

Additional information

Funding

Work in the authors‘ laboratory has been funded by grants from the Christian Doppler Research Society by the Austrian Science Foundations (FWF and FFG), and in part by the Vienna Biocenter PhD Program WK001 (to Denes Hnisz, and Michael Tscherner). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties. No writing assistance was utilized in the production of this manuscript.