The NIH Roadmap Epigenomics Program data Resource

Abstract

The NIH Roadmap Reference Epigenome Mapping Consortium is developing a community resource of genome-wide epigenetic maps in a broad range of human primary cells and tissues. There are large amounts of data already available, and a number of different options for viewing and analyzing the data. This report will describe key features of the websites where users will find data, protocols and analysis tools developed by the consortium, and provide a perspective on how this unique resource will facilitate and inform human disease research, both immediately and in the future.

KEYWORDS::

• chromatin
• data resource
• data visualization
• DNA methylation
• epigenetic mapping
• epigenetics
• epigenomics
• histone modification
• human disease

Acknowledgements

Without the hard work and collegiality of the investigators and NIH staff that make up the Reference Epigenome Mapping Consortium, this data resource would not be possible. The four Reference Epigenome Mapping Centers are headed by J Stamatoyannopoulos (University of Washington, WA, USA), B Bernstein and A Meissner (Broad Institute, MA, USA), B Ren (University of California San Diego, CA, USA) and J Costello (University of California San Fransisco, CA, USA); the Epigenomics Data Analysis and Coordination Center (TX, USA) is led by A Milosavljevic (Baylor College of Medicine, TX, USA); the National Center for Biotechnology Information (NCBI; MD, USA) effort is led by G Schuler (NCBI). The program is directed by staff at the National Institute of Environmental Health Sciences (NC, USA) and the National Institute on Drug Abuse (MD, USA).

Disclaimer

This article may be the work product of an employee or group of employees of the National Institute of Environmental Health Sciences (NIEHS), NIH; however, the statements, opinions or conclusions contained therein do not necessarily represent the statements, opinions or conclusions of NIEHS, NIH or the US government.

Financial & competing interests disclosure

The author is an employee of the NIH. The author has no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

No writing assistance was utilized in the production of this manuscript.

Additional information

Funding

The author is an employee of the NIH. The author has no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. No writing assistance was utilized in the production of this manuscript.