ViralEpi v1.0: A High-Throughput Spectrum of Viral Epigenomic Methylation Profiles from Diverse Diseases

Abstract

Aims: To develop a computational resource for viral epigenomic methylation profiles from diverse diseases. Materials & methods: Methylation patterns of Epstein–Barr virus and hepatitis B virus genomic regions are provided as web platform developed using open source Linux-Apache-MySQL-PHP (LAMP) bundle: programming and scripting languages, that is, HTML, JavaScript and PERL. Results: A comprehensive and integrated web resource ViralEpi v1.0 is developed providing well-organized compendium of methylation events and statistical analysis associated with several diseases. Additionally, it also facilitates ‘Viral EpiGenome Browser’ for user-affable browsing experience using JavaScript-based JBrowse. Conclusion: This web resource would be helpful for research community engaged in studying epigenetic biomarkers for appropriate prognosis and diagnosis of diseases and its various stages.

Keywords::

• biomarkers
• CpG dinucleotides
• epigenomics
• epigenetics
• Epstein–Barr virus
• hepatitis B virus
• methylation

Financial & competing interests disclosure

This work is supported by Council of Scientific and Industrial Research (CSIR; GENESIS-BSC0121) and Department of Biotechnology, Government of India (GAP0001). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

No writing assistance was utilized in the production of this manuscript.

Additional information

Funding

This work is supported by Council of Scientific and Industrial Research (CSIR; GENESIS-BSC0121) and Department of Biotechnology, Government of India (GAP0001). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. No writing assistance was utilized in the production of this manuscript.